Ref: No. RO5/09
Category:- Research, Science & Biotech
Location:- Kilifi
Country:- Kenya
Organization Name:- Kemri-Wellcome Trust Research Programme
Summary
To execute research in the lab which focuses on investigating the functional importance of key parasite molecules expressed on the surface of Plasmodium falciparum-infected red cells in the parasite-host interaction and in naturally acquired immunity to malaria.
Description
Job Title: Research Officer: Role and biology of rifstevor variant antigen gene families in malaria parasites
Department: Immunology and Molecular Parasitology
Location: KEMRI Centre for Geographic Medicine Research, Coast/ Wellcome Trust Research Programme, Kilifi
Grade: 5.4
Salary: Ksh.100, 453
Job Purpose:
To execute research in the lab which focuses on investigating the functional importance of key parasite molecules expressed on the surface of Plasmodium falciparum-infected red cells in the parasite-host interaction and in naturally acquired immunity to malaria.
Current areas of research include:
1) Characterization of sequence diversity and expression patterns of rif and stevor variant gene families in P. falciparum isolates sampled from natural malaria infections;
2) Measurement of naturally acquired antibody responses to the respective encoded antigens expressed in malaria infections, and
3) Sub-Cellular localization and trafficking studies.
Reporting Lines: Post will report to the Principal Investigator
Key Responsibilities:
To support and execute technical aspects of research in the lab under the guidance of the PI involving routine molecular biology and immunological assays, including:
Category:- Research, Science & Biotech
Location:- Kilifi
Country:- Kenya
Organization Name:- Kemri-Wellcome Trust Research Programme
Summary
To execute research in the lab which focuses on investigating the functional importance of key parasite molecules expressed on the surface of Plasmodium falciparum-infected red cells in the parasite-host interaction and in naturally acquired immunity to malaria.
Description
Job Title: Research Officer: Role and biology of rifstevor variant antigen gene families in malaria parasites
Department: Immunology and Molecular Parasitology
Location: KEMRI Centre for Geographic Medicine Research, Coast/ Wellcome Trust Research Programme, Kilifi
Grade: 5.4
Salary: Ksh.100, 453
Job Purpose:
To execute research in the lab which focuses on investigating the functional importance of key parasite molecules expressed on the surface of Plasmodium falciparum-infected red cells in the parasite-host interaction and in naturally acquired immunity to malaria.
Current areas of research include:
1) Characterization of sequence diversity and expression patterns of rif and stevor variant gene families in P. falciparum isolates sampled from natural malaria infections;
2) Measurement of naturally acquired antibody responses to the respective encoded antigens expressed in malaria infections, and
3) Sub-Cellular localization and trafficking studies.
Reporting Lines: Post will report to the Principal Investigator
Key Responsibilities:
To support and execute technical aspects of research in the lab under the guidance of the PI involving routine molecular biology and immunological assays, including:
- Culture of malaria parasites from archived patient samples and laboratory lines.
- DNA/RNA extraction and manipulation.
- Monitoring gene expression using Northern blotting, reverse transcriptase-PCR &/or real-time PCR.
- Preparation of genomic and cDNA libraries of PCR-amplified sequences from parasite samples.
- Recombinant protein expression.
- Immunoprofiling using flow cytometry, ELISA and western blotting.
Data analysis and presentation (under guidance and direction of PI).
Assisting with routine laboratory activities and maintenance.
To support and assist with training of less experienced members of the group, in conjunction with the PI.
Learn new techniques as required.
Skills and Competence:
Assisting with routine laboratory activities and maintenance.
To support and assist with training of less experienced members of the group, in conjunction with the PI.
Learn new techniques as required.
Skills and Competence:
- B.Sc. in biological or medical sciences.
- Experienced in basic molecular biology and/or immunological assays.
- Ability to learn and apply new techniques quickly.
- Work effectively and independently as a team member in a collaborative research environment.
- Good oral and written communication skills.
- Good organisational and prioritisation skills.
- Careful attention to detail.
- An interest in the molecular epidemiology and immunology of infectious diseases, bioinformatics and/or malaria parasite biology would be added advantages.
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Candidates must supply an email and telephone contact that will be used when offering interviews. The application closing date is 15th June 2009. Only shortlisted candidates will be contacted for interviews.
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